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GCN2-IN-1

Names

[ CAS No. ]:
1448693-69-3

[ Name ]:
GCN2-IN-1

[Synonym ]:
MFCD30345302
3-(1H-Indazol-6-yl)-N-[1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine
3H-1,2,3-Triazolo[4,5-d]pyrimidin-5-amine, 3-(1H-indazol-6-yl)-N-[1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-

Biological Activity

[Description]:

GCN2-IN-1 is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with IC50s of <0.3 μM in the enzyme and cell assay.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease
Research Areas >> Cancer

[Target]

IC50: <0.3 μM (GCN2)[1]


[In Vitro]

GCN2-IN-1 (Compound A-92) is a GCN2 inhibitor, which may be useful as a chemotherapeutic drug for the treatment of cancer[1].

[References]

[1]. Brazeau JF, et al. Triazolo[4,5-d]pyrimidine Derivatives as Inhibitors of GCN2. ACS Med Chem Lett. 2014 Feb 12;5(4):282-3.


[Related Small Molecules]

Nafamostat mesylate | WX 671 | UK-371804 | DPP-IV-IN-1

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
760.0±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H18N10O

[ Molecular Weight ]:
402.413

[ Flash Point ]:
413.4±35.7 °C

[ Exact Mass ]:
402.166504

[ LogP ]:
0.87

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.902

[ Storage condition ]:
-20℃

Related Compounds