VL285 Phenol

Names

[ Name ]:
VL285 Phenol

Biological Activity

[Description]:

VL285 Phenol is a VL285 analogue with Phenol group. VL285, a small molecule VHL ligand, can be served as a degrader for HaloPROTAC3 synthesis.VL285 degrades HaloTag7 fusion proteins (IC50=0.34 μM)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

VL285（100 μM；24 小时）减弱 HaloPROTAC3 诱导 GFP-HaloTag7 降解的能力[1]。

[References]

[1]. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₃₂N₄O₅S

[ Molecular Weight ]:
548.65

Related Compounds

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