Ald-CH2-PEG5-Boc

Names

[ CAS No. ]:
1446282-23-0

[ Name ]:
Ald-CH2-PEG5-Boc

[Synonym ]:
ALD-CH2-PEG5-T-BUTYL ESTER

Biological Activity

[Description]:

Ald-CH2-PEG5-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
440.5±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₃₂O₈

[ Molecular Weight ]:
364.431

[ Flash Point ]:
189.0±27.4 °C

[ Exact Mass ]:
364.209717

[ LogP ]:
-0.28

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.448

Related Compounds

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