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Hematoporphyrin

Names

[ CAS No. ]:
14459-29-1

[ Name ]:
Hematoporphyrin

[Synonym ]:
EINECS 238-450-7
Photodyn
HematoporphyrineBase
MFCD00005077
3,3'-[7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-2,18-porphyrindiyl]dipropanoic acid
1,3,5,8-Tetramethyl-2,4-bis(a-hydroxyethyl)porphine-6,7-dipropionic Acid
21H,23H-Porphine-2,18-dipropanoic acid, 8,13-bis(1-hydroxyethyl)-3,7,12,17-tetramethyl-
3,3'-[7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethylporphyrin-2,18-diyl]dipropanoic acid
Hematoporphyrin
Sensibion

Biological Activity

[Description]:

Hematoporphyrin (Hematoporphyrin IX) is a substrate for affinity chromatography of heme-binding proteins.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Others

[In Vitro]

Hematoporphyrin is used for affinity chromatography of heme-binding proteins. Hematoporphyrin is used in the characterization and synthesis of hematoporphyrin- and hematin-agarose [1].

[References]

[1]. Olsen, K.W., Affinity chromatography of heme-binding proteins: synthesis and characterization of hematin- and hematoporphyrin-agarose. Methods Enzymol, 1986. 123: p. 324-31.


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Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
1179.7±65.0 °C at 760 mmHg

[ Melting Point ]:
172.5°C

[ Molecular Formula ]:
C34H38N4O6

[ Molecular Weight ]:
598.689

[ Flash Point ]:
667.3±34.3 °C

[ Exact Mass ]:
598.279114

[ PSA ]:
171.36000

[ LogP ]:
5.95

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.642

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TS5500000
CHEMICAL NAME :
2,18-Porphinedipropionic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-
CAS REGISTRY NUMBER :
14459-29-1
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C34-H38-N4-O6
MOLECULAR WEIGHT :
598.76
WISWESSER LINE NOTATION :
T D5 I5 N5-16-5 A D- I- N- AM D-N I-M N-NJ EYQ F J K2VQ O2VQ TYQ U

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
307 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - mouse Leukocyte
DOSE/DURATION :
1 mg/L
REFERENCE :
TUMOAB Tumori. (Casa Editrice Ambrosiana, Via G. Frua 6, 20146 Milan, Italy) V.1- 1911- Volume(issue)/page/year: 67,183,1981

Safety Information

[ Safety Phrases ]:
22-24/25

[ WGK Germany ]:
3

[ RTECS ]:
TS5500000

Synthetic Route

Click to get detail synthetic route

Related Compounds

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