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Landiolol Hydrochloride

Names

[ CAS No. ]:
144481-98-1

[ Name ]:
Landiolol Hydrochloride

[Synonym ]:
((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-(4-((S)-2-hydroxy-3-(2-(morpholine-4-carboxamido)ethylamino)propoxy)phenyl)propanoate hydrochloride
[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(2S)-2-hydroxy-3-[2-(morpholine-4-carbonylamino)ethylamino]propoxy]phenyl]propanoate hydrochloride
(-)-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl-3-[4-[(S)-2-hydroxy-3-(2-morpholinocarbonylamino)ethylamino]propoxy]phenylpropionic acid hydrochloride
(-)-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(S)-2-hydroxy-3-(2-(morpholinocarbonylamino)ethylamino)propoxy]phenyl]propionate monohydrochloride
Benzenepropanoic acid,4-(2-hydroxy-3-((2-((4-morpholinylcarbonyl)amino)ethyl)amino)propoxy)-,(2,2-dimethyl-1,3-dioxolan-4-yl)methyl ester,(S-(R*,R*))-,hydrochloride
Landiololhydrochloride
Benzenepropanoic acid, 4-[(2S)-2-hydroxy-3-[[2-[(4-morpholinylcarbonyl)amino]ethyl]amino]propoxy]-, [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl ester, hydrochloride (1:1)
Ono 1101 hydrochloride
2,2-dimethyl-1,3-dioxolan-4S-yl-methyl 3-[P-{3-{(2-(morpholinocarbonylamino)ethyl)amino}-2S-hydroxypropoxy}phenyl] propionate hydrochloride
[(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]methyl 3-{4-[(2S)-2-hydroxy-3-({2-[(4-morpholinylcarbonyl)amino]ethyl}amino)propoxy]phenyl}propanoate hydrochloride (1:1)

Biological Activity

[Description]:

Landiolol hydrochloride (ONO1101 hydrochloride) is a highly beta1 selective ultra-short acting beta-blocker (β1/β2 selectivity = 255:1, a half-life of 4 min), acts as an adrenoceptor antagonist[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[Target]

beta-adrenergic receptor[1]


[References]

[1]. Atarashi H, et al. Pharmacokinetics of landiolol hydrochloride, a new ultra-short-acting beta-blocker, in patients with cardiac arrhythmias. Clin Pharmacol Ther. 2000 Aug;68(2):143-50.

[2]. Okajima M, et al. Landiolol, an ultra-short-acting β1-blocker, is useful for managing supraventricular tachyarrhythmias in sepsis. World J Crit Care Med. 2015 Aug 4;4(3):251-7.

Chemical & Physical Properties

[ Density]:
1.201g/cm3

[ Boiling Point ]:
727.5ºC at 760mmHg

[ Melting Point ]:
122-127ºC

[ Molecular Formula ]:
C25H40ClN3O8

[ Molecular Weight ]:
546.053

[ Flash Point ]:
393.8ºC

[ Exact Mass ]:
545.250366

[ PSA ]:
127.82000

[ LogP ]:
2.37760

[ Vapour Pressure ]:
3.24E-22mmHg at 25°C

Safety Information

[ RTECS ]:
DA8346700

Synthetic Route


Related Compounds