Enzalutamide D3

Names

[ Name ]:
Enzalutamide D3

[Synonym ]:
4-{3-[3-Cyano-4-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl}-2-fluoro-N-(2H3)methylbenzamide
Benzamide, 4-[3-[3-cyano-4-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-(methyl-d3)-

Biological Activity

[Description]:

Enzalutamide D3 is a deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> Others >> Androgen Receptor

[References]

[1]. Tran C, et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science. 2009 May 8;324(5928):787-90.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₂₁H₁₃D₃F₄N₄O₂S

[ Molecular Weight ]:
467.454

[ Exact Mass ]:
467.111847

[ LogP ]:
2.13

[ Index of Refraction ]:
1.630

Related Compounds

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