Enzalutamide carboxylic acid

Names

[ Name ]:
Enzalutamide carboxylic acid

[Synonym ]:
Enzalutamide Impurity 1

Biological Activity

[Description]:

Enzalutamide carboxylic acid (MDV3100 carboxylic acid) is an inactive metabolite of Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist[1].

[Related Catalog]:

Research Areas >> Cancer

[In Vitro]

Enzalutamide is converted into its major metabolites, N-desmethyl enzalutamide and carboxylic acid enzalutamide, by cytochrome P450 (CYP) 3A4/5 and CYP2C8, respectively. N-desmethyl enzalutamide has clinically relevant anti-androgen capacities similar to enzalutamide, whereas carboxylic acid enzalutamide is inactive[1].

[References]

[1]. van Nuland M, et al. Exposure-Response Assessment of Enzalutamide and Its Major Metabolites in a Real-World Cohort of Patients with Metastatic Castration-Resistant Prostate Cancer. Pharmacotherapy. 2019 Dec;39(12):1137-1145.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₃F₄N₃O₃S

[ Molecular Weight ]:
451.39400

[ Exact Mass ]:
451.06100

[ PSA ]:
116.73000

[ LogP ]:
4.46108

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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