ICMT-IN-53

Names

[ CAS No. ]:
1443253-17-5

[ Name ]:
ICMT-IN-53

Biological Activity

[Description]:

ICMT-IN-53 (compound 12) is an ICMT inhibitor (IC50=0.96 μM) with PAMPA permeability and antiproliferative activity. ICMT-IN-53 inhibits the proliferation of MDA-MB-231 and PC3 with IC50s of 5.14 μM and 5.88 μM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

IC50: 0.96 μM (ICMT)[1]


[References]

[1]. Ramanujulu PM, et al. Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt). Eur J Med Chem. 2013 May;63:378-86.  

Chemical & Physical Properties

[ Molecular Formula ]:
C26H36FN3

[ Molecular Weight ]:
409.58

Related Compounds

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