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DMT-2'Fluoro-DG(IB) Amidite

Names

[ CAS No. ]:
144089-97-4

[ Name ]:
DMT-2'Fluoro-DG(IB) Amidite

[Synonym ]:
9-{(3ξ)-5-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2-deoxy-2-fluoro-β-D-threo-pentofuranosyl}-2-(isobutyrylamino)-1,9-dihydro-6H-purin-6-one
6H-Purin-6-one, 9-[(3ξ)-5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-2-fluoro-β-D-threo-pentofuranosyl]-1,9-dihydro-2-[(2-methyl-1-oxoprop yl)amino]-

Biological Activity

[Description]:

DMT-2'Fluoro-DG(IB) Amidite (2'-F-ibu-dG Phosphoramidite) is a nucleoside that can be used in the preparation of 4'-modified 2'-deoxy-2'-fluorouridine[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[References]

[1]. Elise Malek-Adamian, et al. 4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing. J Am Chem Soc. 2017 Oct 18;139(41):14542-14555.

Chemical & Physical Properties

[ Molecular Formula ]:
C44H53FN7O8P

[ Molecular Weight ]:
857.906

[ Exact Mass ]:
857.367737

[ LogP ]:
9.87

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Related Compounds