sulfacetamide
Names
[ CAS No. ]:
144-80-9
[ Name ]:
sulfacetamide
[Synonym ]:
A-500
N-(4-Aminobenzenesulfonyl)acetamide (N-(4-Aminophenylsulfonyl)acetamide
Solfacetamide [DCIT]
Alesten
EINECS 205-640-6
Acetocid
Oclucid
Sulamyd
N-[(4-Aminophenyl)sulfonyl]acetamide
sulfacetamidum
ALBUCID SOLUBLE
Acetamide, N-[(4-aminophenyl)sulfonyl]-
N-Acetylsulfanilamide
Sebizon
sultrin
N1-acetylsulfanilamide
I-Sulfacet
Prontamid
Sulfacet
Sulfair
Acetamide, N-((4-aminophenyl)sulfonyl)-
Isopto-Cetamide
N-acetyl-4-aminobenzenesulfonamide
sulfacetamide
Locula
Ak-Sulf
sulfacetamida
N-((4-Aminophenyl)sulfonyl)acetamide
Sulfacetimide
Region
Beocid-isoptal
Antebor
Albucid
MFCD00066501
Sulf-10
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Melting Point ]:
182-184 °C
[ Molecular Formula ]:
C8H10N2O3S
[ Molecular Weight ]:
214.242
[ Exact Mass ]:
214.041214
[ PSA ]:
97.64000
[ LogP ]:
-0.96
[ Vapour Pressure ]:
0.04mmHg at 25°C
[ Index of Refraction ]:
1.584
[ Storage condition ]:
0-6°C
[ Stability ]:
Stable. Incompatible with strong oxidizing agents, strong bases, strong reducing agents, strong acids.
[ Water Solubility ]:
<0.01 g/100 mL at 16 ºC
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AC8450000
- CHEMICAL NAME :
- Acetamide, N-sulfanilyl-
- CAS REGISTRY NUMBER :
- 144-80-9
- BEILSTEIN REFERENCE NO. :
- 0981718
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 14
- MOLECULAR FORMULA :
- C8-H10-N2-O3-S
- MOLECULAR WEIGHT :
- 214.26
- WISWESSER LINE NOTATION :
- ZR DSWMV1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 16500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 606 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex)
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 8 gm/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - rigidity (including catalepsy)
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 5 gm/kg
- TOXIC EFFECTS :
- Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 10 gm/kg
- SEX/DURATION :
- female 10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 1 gm/L
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80537 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80537 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1639 (estimated) No. of Female Employees: 1344 (estimated)
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
R20/21/22
[ Safety Phrases ]:
S22-S24/25
[ RIDADR ]:
3249
[ WGK Germany ]:
2
[ RTECS ]:
AC8450000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
2935009090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2924299090
[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
J. Sci. Ind. Res. 65(10) , 808, (2006)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...
Simultaneous determination of sulfonamides and metabolites in manure samples by one-step ultrasound/microwave-assisted solid-liquid-solid dispersive extraction and liquid chromatography-mass spectrometry.Anal. Bioanal. Chem 407(13) , 3545-54, (2015)
An in-line matrix cleanup method was used for the simultaneous extraction of 15 sulfonamides and two metabolites from manure samples. The ultrasound/microwave-assisted extraction (UMAE) combined with ...
Concentration and distribution of antibiotics in water-sediment system of Bosten Lake, Xinjiang.Environ. Sci. Pollut. Res. Int. 22(3) , 1670-8, (2015)
This study investigated the residues of four sulfonamides, four quinolones, and four tetracyclines in surface water as well as surficial sediment samples, of Bosten Lake, in Xinjiang, China. The resul...