L685818

L685818 is a specific immunophilin ligand. L685818 was neuroregenerative and non-neuroprotective in primary brain cultures. L685818 protects dopaminergic neurons from toxic inhibition of MPP+ and 6-OHDA, reduces tyrosine hydroxylase (TH) loss, and promotes neuronal process regeneration. L685818 is also an antifungal reagent for Cryptococcus neoformans[1][2].

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Research Areas >> Neurological Disease

L685818 (100 nM; MPP+ 组处理 2 天, 6-OHDA组处理 24 h) 具有神经保护作用，在 MPP+ 和 6-OHDA 抑制下，增加 TH+ 细胞的数目[1]。 L685818 (10-100 nM; 24 h) 防止 MPP+ 和 6-OHDA (HY-B1081) 处理引起的酪氨酸羟化酶 (TH) 损失[1]。 L685818 (0.01-1 μM; 24 h) 防止 MPP+ 和 6-OHDA 导致神经元突起的收缩和丢失，促进突起再生[1]。

[1]. Guo X, et al. Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons. Eur J Neurosci. 2001 May;13(9):1683-93.  

[2]. Odom A, et al. The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein. Antimicrob Agents Chemother. 1997 Jan;41(1):156-61.