Hydroquinidine
Names
[ CAS No. ]:
1435-55-8
[ Name ]:
Hydroquinidine
[Synonym ]:
EINECS 215-862-5
HYDROQUINIDINE
(9S)-6'-Methoxy-10,11-dihydrocinchonan-9-ol
MFCD00135599
(+)-Dihydroquinidine
(9S)-10,11-Dihydro-6'-methoxycinchonan-9-ol
Cinchonan-9-ol, 10,11-dihydro-6'-methoxy-, (9S)-
dihydroquinidine
hydroconchinine
Biological Activity
[Description]:
[Related Catalog]:
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
498.4±30.0 °C at 760 mmHg
[ Melting Point ]:
169-170 ºC
[ Molecular Formula ]:
C20H26N2O2
[ Molecular Weight ]:
326.433
[ Flash Point ]:
255.2±24.6 °C
[ Exact Mass ]:
326.199432
[ PSA ]:
45.59000
[ LogP ]:
3.77
[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C
[ Index of Refraction ]:
1.626
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MX3016000
- CHEMICAL NAME :
- Hydroquinidine
- CAS REGISTRY NUMBER :
- 1435-55-8
- LAST UPDATED :
- 199607
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C20-H26-N2-O2
- MOLECULAR WEIGHT :
- 326.48
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 12 mg/kg
- TOXIC EFFECTS :
- Behavioral - hallucinations, distorted perceptions Behavioral - headache Cardiac - EKG changes not diagnostic of specified effects
- REFERENCE :
- CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 18,659,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 56500 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 84,184,1945
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302 + H312 + H332
[ Precautionary Statements ]:
P280
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
20/21/22
[ Safety Phrases ]:
36/37-36
[ RIDADR ]:
UN 1544
[ WGK Germany ]:
3
[ RTECS ]:
MX3016000
[ Packaging Group ]:
III
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
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Phenylalanine ammonia-lyase (PAL) is an important enzyme that links primary metabolism to secondary metabolism. Its efficiency is often a critical factor that affects the overall flux of a related met...
Macromolecular crowding-assisted fabrication of liquid-crystalline imprinted polymers.Anal. Bioanal. Chem 407(10) , 2923-31, (2015)
A macromolecular crowding-assisted liquid-crystalline molecularly imprinted monolith (LC-MIM) was prepared successfully for the first time. The imprinted stationary phase was synthesized with polymeth...
A (p)ppGpp-null mutant of Haemophilus ducreyi is partially attenuated in humans due to multiple conflicting phenotypes.Infect. Immun. 82(8) , 3492-502, (2014)
(p)ppGpp responds to nutrient limitation through a global change in gene regulation patterns to increase survival. The stringent response has been implicated in the virulence of several pathogenic bac...