Bryostatin 3

Names

[ Name ]:
Bryostatin 3

[Synonym ]:
(1S,3Z,5R,7Z,9S,11S,13S,15R,17R,21R,23R,24S,29S)-13-Acetoxy-1,11,17-trihydroxy-21-[(1R)-1-hydroxyethyl]-7-(2-methoxy-2-oxoethylidene)-2,2,12,12-tetramethyl-19,26-dioxo-20,25,30,31,32-pentaoxapentacycl ;o[21.6.1.1.1.0]dotriaconta-3,27-dien-29-yl (2E,4E)-2,4-octadienoate

Biological Activity

[Description]:

Bryostatin 3, a macrocyclic lactone, is a protein kinase C activator, with a Ki of 2.75 nM. Bryostatin 3 can block 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibition of cell proliferation, yet did not block TPA-enhanced cell-substratum adhesion[1][2].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC

Research Areas >> Cancer

Signaling Pathways >> TGF-beta/Smad >> PKC

[Target]

Ki: 2.75 nM (protein kinase C)[1]

[In Vitro]

Bryostatin 3 (1 μM; 24 h) does not inhibit [3Hlthymidine incorporation and largely blocks the growth-inhibitory action of TPA[2]. Bryostatin 3 (1 μM; 24 h) blocks the action of TPA to inhibit cell proliferation but does not block TPA-enhanced cell-substratum adhesion[2].

[References]

[1]. Wender PA, et, al. Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C. Proc Natl Acad Sci U S A. 1988 Oct;85(19):7197-201.

[2]. Mackanos EA, et, al. Bryostatins selectively regulate protein kinase C-mediated effects on GH4 cell proliferation. J Biol Chem. 1991 Jun 15;266(17):11205-12.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
993.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₆H₆₄O₁₇

[ Molecular Weight ]:
888.99

[ Flash Point ]:
286.2±27.8 °C

[ Exact Mass ]:
888.414368

[ LogP ]:
4.17

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.579

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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