IDH-889
Names
[ CAS No. ]:
1429179-07-6
[ Name ]:
IDH-889
Biological Activity
[Description]:
IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 μM[1].
[Related Catalog]:
[Target]
IC50: 0.02 μM (IDH1R132H), 0.072 μM (IDH1R132C), 1.38 μM (IDH1wt)[1]
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C23H25FN6O2
[ Molecular Weight ]:
436.48