IDH-C227

Names

[ CAS No. ]:
1355324-14-9

[ Name ]:
IDH-C227

Biological Activity

[Description]:

IDH-C227 is a potent and selective IDH1R132H inhibitor. IDH-C227 has anticancer effcts[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Isocitrate Dehydrogenase (IDH)

[In Vitro]

IDH-C227 shows anticancer effcts, with IC50 values of <0.1 μM and 0.25 μM against HT1080 and U87MG cells, respectively[1].

[References]

[1]. Hanumantha Rao Madala, et al. Beyond Brooding on Oncometabolic Havoc in IDH-Mutant Gliomas and AML: Current and Future Therapeutic Strategies. Cancers (Basel). 2018 Feb 11;10(2):49.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₃₁FN₄O₂

[ Molecular Weight ]:
498.59100

[ Exact Mass ]:
498.24300

[ PSA ]:
85.23000

[ LogP ]:
6.10498

Related Compounds

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