N4-Acetylcytidine triphosphate

Names

[ Name ]:
N4-Acetylcytidine triphosphate

Biological Activity

[Description]:

N4-Acetylcytidine triphosphate is a endogenous nucleoside metabolite from the degradation of tRNA, primes and activates NLRP3 inflammation by inducing HMGB1 expression[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR)

Research Areas >> Inflammation/Immunology

[Target]

NLRP3[1]

[In Vitro]

N4-Acetylcytidine (0.3  mM or 1.0  mM) upregulates NF-κB and NLRP3 expression BV2 microglia, and this calls for HMGB1 expression and release[1].

[References]

[1]. Duan J, et al. N4-acetylcytidine is required for sustained NLRP3 inflammasome activation via HMGB1 pathway in microglia. Cell Signal. 2019 Mar 7;58:44-52.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₁₈N₃O₁₅P₃

[ Molecular Weight ]:
525.19

Related Compounds

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