1428903-57-4

1428903-57-4 structure

Name: N4-Acetylcytidine triphosphate
Chemical Name: N4-Acetylcytidine triphosphate
CAS Number: 1428903-57-4
Molecular Formula: C₁₁H₁₈N₃O₁₅P₃
Molecular Weight: 525.19
Catalog: Signaling Pathways Immunology/Inflammation NOD-like Receptor (NLR)
Create Date: 2019-06-01 19:11:56
Modify Date: 2024-01-11 08:57:30
N4-Acetylcytidine triphosphate is a endogenous nucleoside metabolite from the degradation of tRNA, primes and activates NLRP3 inflammation by inducing HMGB1 expression[1].

Name	N4-Acetylcytidine triphosphate

Description	N4-Acetylcytidine triphosphate is a endogenous nucleoside metabolite from the degradation of tRNA, primes and activates NLRP3 inflammation by inducing HMGB1 expression[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR) Research Areas >> Inflammation/Immunology
Target	NLRP3[1]
In Vitro	N4-Acetylcytidine (0.3  mM or 1.0  mM) upregulates NF-κB and NLRP3 expression BV2 microglia, and this calls for HMGB1 expression and release[1].
References	[1]. Duan J, et al. N4-acetylcytidine is required for sustained NLRP3 inflammasome activation via HMGB1 pathway in microglia. Cell Signal. 2019 Mar 7;58:44-52.

Molecular Formula	C₁₁H₁₈N₃O₁₅P₃
Molecular Weight	525.19