VPM peptide

Names

[ Name ]:
VPM peptide

Biological Activity

[Description]:

VPM peptide is a dithiol protease-cleavable peptide cross-linker. VPM peptide can be incorporated into the backbone of the PEG-diacrylate (PEG-DA) macromer to form PEG hydrogel[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

VPM peptide is rapidly cleaved by matrix metalloproteinase (MMP)-1 and MMP-2 proteases[2]. VPM-crosslinked microgels are degradable by proteases in a concentration-dependent manner[2].

[References]

[1]. Phelps EA, et, al. Maleimide cross-linked bioactive PEG hydrogel exhibits improved reaction kinetics and cross-linking for cell encapsulation and in situ delivery. Adv Mater. 2012 Jan 3;24(1):64-70, 2

[2]. Foster GA, et, al. Protease-degradable microgels for protein delivery for vascularization. Biomaterials. 2017 Jan;113:170-175.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₃H₁₀₉N₂₅O₂₂S₄

[ Molecular Weight ]:
1696.95

Related Compounds

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