HXJ 42

Names

[ Name ]:
HXJ 42

Biological Activity

[Description]:

A PP1 analog that has greater selectivity and potency for Zap-70(AS) over wild-type Zap-70, as assessed by Erk and Lat phosphorylation, as well as by proliferative responses of mature CD4+ cells; effectively rescues Zap70(AS) OT-I cells from negative selection.

[References]

References 1. Au-Yeung BB, et al. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3679-88. 2. Au-Yeung BB, et al. Nat Immunol. 2014 Jul;15(7):687-94. View Related Products by Target T Cell Receptor (TCR)

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₅Cl₂N₅O

[ Molecular Weight ]:
352.219

Related Compounds

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