V-11-0711

V-11-0711 (V-11 0711) is a novel potent and selective choline kinase alpha (ChoKα) inhibitor with IC50 of 20 nM, with 11 fold less activity against ChoKβ; exhibits excellent selectivity against a panel of 50 kinases; impedes the catalytic activity and causes a reversible growth arrest, reduces phosphocholine (Pcho) in Hela cells with IC50 of <1 uM; also shows synergetic cytotoxic effects combined with chemotherapeutic temozolomide in some cancer cell lines.

References 1. Falcon SC, et al. Oncogenesis. 2013;2:e38. 2. Koch K, et al. Oncotarget. 2016 Nov 8;7(45):73414-73431. View Related Products by Target Choline Kinase (ChoK)