1428339-47-2
1428339-47-2 structure
- Name: V-11-0711
- Chemical Name: V-11-0711
- CAS Number: 1428339-47-2
- Molecular Formula: C27H35NO3
- Molecular Weight: 421.581
- Catalog: Research Areas Cancer
- Create Date: 2020-01-11 21:48:15
- Modify Date: 2024-01-09 12:29:54
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V-11-0711 (V-11 0711) is a novel potent and selective choline kinase alpha (ChoKα) inhibitor with IC50 of 20 nM, with 11 fold less activity against ChoKβ; exhibits excellent selectivity against a panel of 50 kinases; impedes the catalytic activity and causes a reversible growth arrest, reduces phosphocholine (Pcho) in Hela cells with IC50 of <1 uM; also shows synergetic cytotoxic effects combined with chemotherapeutic temozolomide in some cancer cell lines.
| Name | V-11-0711 |
|---|
| Description | V-11-0711 (V-11 0711) is a novel potent and selective choline kinase alpha (ChoKα) inhibitor with IC50 of 20 nM, with 11 fold less activity against ChoKβ; exhibits excellent selectivity against a panel of 50 kinases; impedes the catalytic activity and causes a reversible growth arrest, reduces phosphocholine (Pcho) in Hela cells with IC50 of <1 uM; also shows synergetic cytotoxic effects combined with chemotherapeutic temozolomide in some cancer cell lines. |
|---|---|
| References | References 1. Falcon SC, et al. Oncogenesis. 2013;2:e38. 2. Koch K, et al. Oncotarget. 2016 Nov 8;7(45):73414-73431. View Related Products by Target Choline Kinase (ChoK) |
| Molecular Formula | C27H35NO3 |
|---|---|
| Molecular Weight | 421.581 |