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(3S,5S)-Atorvastatin (sodium salt)

Names

[ CAS No. ]:
1428118-38-0

[ Name ]:
(3S,5S)-Atorvastatin (sodium salt)

Biological Activity

[Description]:

(3S,5S)-Atorvastatin sodium salt is a pregnane X receptor (PXR) activator and the inactive enantiomer of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor with lipid-lowering capabilities[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Research Areas >> Others

[Target]

Pregnane X receptor (PXR)[1].


[References]

[1]. Kocarek TA, et al. Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes. Drug Metab Dispos. 2002 Dec;30(12):1400-5.  

[2]. Korhonova M, et al. Optical Isomers of Atorvastatin, Rosuvastatin and Fluvastatin Enantiospecifically Activate Pregnane X Receptor PXR and Induce CYP2A6, CYP2B6 and CYP3A4 in Human Hepatocytes. PLoS One. 2015 Sep 14;10(9):e0137720.  

[3]. Shcherbakova EG, et al. High-Throughput Assay for Enantiomeric Excess Determination in 1,2- and 1,3-Diols and Direct Asymmetric Reaction Screening. Chemistry. 2017 Jul 26;23(42):10222-10229.  

Chemical & Physical Properties

[ Molecular Formula ]:
C33H34FN2NaO5

[ Molecular Weight ]:
580.62

Related Compounds