4-Chlorophenylguanidine hydrochloride

Names

[ Name ]:
4-Chlorophenylguanidine hydrochloride

[Synonym ]:
bw 65-100
4-chlorophenylguanidine hydrochloride
4-chlorophenylguanidine

Biological Activity

[Description]:

4-Chlorophenylguanidine hydrochloride is a potent ASIC3 positive allosteric modulator and reverses the effects of ASIC3 desensitization. 4-Chlorophenylguanidine hydrochloride influences ASIC3 activity through directly activating the channel and increasing proton sensitivity. 4-Chlorophenylguanidine hydrochloride offers a chemical backbone for the design of new ASIC3 ligands to study ASIC3 in vivo[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Research Areas >> Neurological Disease

[References]

[1]. Amruta S Agharkar, et al. 4-Chlorophenylguanidine is an ASIC3 agonist and positive allosteric modulator. J Pharmacol Sci. 2017 Mar;133(3):184-186.

Chemical & Physical Properties

[ Boiling Point ]:
333.9ºC at 760mmHg

[ Molecular Formula ]:
C₇H₉Cl₂N₃

[ Molecular Weight ]:
206.07

[ Flash Point ]:
155.7ºC

[ Exact Mass ]:
205.01700

[ PSA ]:
61.90000

[ LogP ]:
3.32040

[ Vapour Pressure ]:
0.000133mmHg at 25°C

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2925290090

Customs

[ HS Code ]: 2925290090

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%