Thailanstatin C

Names

[ Name ]:
Thailanstatin C

Biological Activity

[Description]:

Thailanstatin C is a pre-mRNA splicing inhibitor (IC50= 6.84 μM) and antiproliferative agent from Burkholderia thailandensis MSMB43[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[In Vitro]

Thailanstatin C inhibits human cancer cell lines with IC50s of 2.98-8.82 nM for DU-145, NCI-H232A, MDA-MB-231 and SKOV-3 cells[1].

[References]

[1]. Liu X, et al. Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43. J Nat Prod. 2013;76(4):685-693.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₄₆ClNO₉

[ Molecular Weight ]:
600.14

Related Compounds

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