NHS-SS-(+)-Biotin

Names

[ Name ]:
NHS-SS-(+)-Biotin

[Synonym ]:
Succinimidyl 3-[3-[2-(biotinamido)ethyl]amino-3-oxopropyl]dithio]propionate
NHS-SS-Biotin
Biotin disulfide N-hydroxysuccinimide ester
(2-[Biotinamido]ethylamido)-3,3 inverted exclamation marka-dithiodipropionic acid N-hydroxysuccinimide ester

Biological Activity

[Description]:

Biotin-bis-amido-SS-NHS is an Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[In Vitro]

Biotin-bis-amido-SS-NHS is a long arm biotin containing disulfide bond, and the compound can be applied to biochemistry detection field, reduce the influence of steric effect, improve the sensitivity of detection[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Liyanping, et al. A kind of long arm biotin containing disulfide bond and preparation method thereof. Patent CN107383054A.

Chemical & Physical Properties

[ Density]:
1.43

[ Melting Point ]:
129-131ºC

[ Molecular Formula ]:
C₂₂H₃₃N₅O₇S₃

[ Molecular Weight ]:
575.72200

[ Exact Mass ]:
575.15400

[ PSA ]:
238.91000

[ LogP ]:
2.09070

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H360D

[ Precautionary Statements ]:
P201-P308 + P313

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
61

[ Safety Phrases ]:
53-23-36/37/39-45

[ RIDADR ]:
NONH for all modes of transport

Articles

Chemical probes of extended biological structures: synthesis and properties of the cleavable protein cross-linking reagent [35S]dithiobis(succinimidyl propionate).

J. Mol. Biol. 104 , 243-261, (1976)

A mechanism-based affinity-labeling agent for possible use in isolating N-acetylglucosaminidase.

Bioorg. Med. Chem. Lett. 11 , 1769-1773, (2001)

We have prepared several mechanism-based affinity-labeling agents for possible use in isolating N-acetylglucosaminidase, in which an N-acetylglucosamine is linked to an o-monofluoro- or difluoro-methy...

A dominant linear B-cell epitope of ricin A-chain is the target of a neutralizing antibody response in Hodgkin's lymphoma patients treated with an anti-CD25 immunotoxin.

Clin. Exp. Immunol. 136 , 365-372, (2004)

Hodgkin's lymphoma patients treated with an anti-CD25 Ricin toxin A-chain (RTA)-based Immunotoxin (RFT5.dgA) develop an immune response against the toxic moiety of the immunoconjugate. The anti-RTA an...

Related Compounds

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