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Shizukaol B

Names

[ CAS No. ]:
142279-40-1

[ Name ]:
Shizukaol B

Biological Activity

[Description]:

Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and IL-1β expression[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related
Signaling Pathways >> Immunology/Inflammation >> NO Synthase
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-2

iNOS

IL-1β


[In Vitro]

Shizukaol B (25 μM; 0-60 min) 抑制 LPS (1 μg/mL; 0-60 min) 介导的 c-Jun N 末端激酶 1/2 (JNK) 激活，不影响 ERK1/2 或 p38 磷酸化[1]。 Shizukaol B (12.5-50 μM; 4 h) 抑制 LPS 诱导 (1 μg/mL; 24 h) 的 NO 生成，抑制 iNOS 和 COX-2 的表达[1]。

[References]

[1]. Pan LL, et al. Shizukaol B, an active sesquiterpene from Chloranthus henryi, attenuates LPS-induced inflammatory responses in BV2 microglial cells. Biomed Pharmacother. 2017 Apr;88:878-884.  

Chemical & Physical Properties

[ Molecular Formula ]:
C40H44O13

[ Molecular Weight ]:
732.77000

[ Exact Mass ]:
732.27800

[ PSA ]:
189.03000

[ LogP ]:
2.37710

Related Compounds