endo-BCN-PEG2-PFP ester

Names

[ CAS No. ]:
1421932-53-7

[ Name ]:
endo-BCN-PEG2-PFP ester

[Synonym ]:
2,7,10-Trioxa-4-azatridecan-13-oic acid, 1-bicyclo[6.1.0]non-4-yn-9-yl-3-oxo-, 2,3,4,5,6-pentafluorophenyl ester
Pentafluorophenyl 1-(bicyclo[6.1.0]non-4-yn-9-yl)-3-oxo-2,7,10-trioxa-4-azatridecan-13-oate

Biological Activity

[Description]:

endo-BCN-PEG2-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
586.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₂₆F₅NO₆

[ Molecular Weight ]:
519.458

[ Flash Point ]:
308.3±30.1 °C

[ Exact Mass ]:
519.168030

[ LogP ]:
4.16

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.520

Related Compounds

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