PF-06263276

Names

[ Name ]:
PF-06263276

Biological Activity

[Description]:

PF-06263276 (PF 6263276) is a potent and selective pan-JAK inhibitor, with IC50s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1, JAK2, JAK3 and TYK2, respectively[1].

[Related Catalog]:

Signaling Pathways >> JAK/STAT Signaling >> JAK

Signaling Pathways >> Epigenetics >> JAK

Signaling Pathways >> Stem Cell/Wnt >> JAK

Research Areas >> Inflammation/Immunology

[Target]

JAK1:2.2 nM (IC50)

JAK2:23.1 nM (IC50)

JAK3:59.9 nM (IC50)

Tyk2:29.7 nM (IC50)

[References]

[1]. Jones P, et al. Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin. J Med Chem. 2017 Jan 26;60(2):767-786.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₁H₃₁FN₈O₂

[ Molecular Weight ]:
566.638

[ Appearance of Characters ]:
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Related Compounds

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