las191859

Names

[ CAS No. ]:
1420071-13-1

[ Name ]:
las191859

Biological Activity

[Description]:

LAS191859 is an orally active, potent and selective CRTh2 antagonist with an IC50 of 9.58 nM against human CRTh2. LAS191859 can be used for the research of chronic asthma[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor

Research Areas >> Inflammation/Immunology

[Target]

IC50: 7.6 nM (guinea pig CRTh2), 9.58 nM (human CRTh2), 14 nM (rat CRTh2), 15.5 nM (mouse CRTh2)[1]

[References]

[1]. Calbet M, et al. Pharmacological characterization of CRTh2 antagonist LAS191859: Long receptor residence time translates into long-lasting in vivo efficacy. Pharmacol Res. 2016 Sep;111:208-216.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₄F₃N₃O₃

[ Molecular Weight ]:
459.46

Related Compounds

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