sFTX-3.3

Names

[ CAS No. ]:
141997-14-0

[ Name ]:
sFTX-3.3

Biological Activity

[Description]:

sFTX-3.3 is a Ca2+ channel antagonist with IC50s of approximately 0.24 mM and 0.70 mM against P-type and N-type channels[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Research Areas >> Neurological Disease

[Target]

P-type calcium channel:0.24 mM (IC50)

N-Type Ca2+ Channel:0.70 mM (IC50)

[In Vitro]

sFTX-3.3 (100 μM) reduces the duration of the slow component of presynaptic calcium currents by about 50% of the control and also reduces presynaptic sodium current by approximately 20% of the control. sFTX-3.3 (100 μM) reduces whole-cell sodium current recorded from SK.N.SH cells by approximately 15%[3].

[References]

[1]. Maria Elisa Calcagnotto, et al. An examination of calcium current function on heterotopic neurons in hippocampal slices from rats exposed to methylazoxymethanol. Epilepsia. 2003 Mar;44(3):315-21.

[2]. T M Norris, et al. Block of high-threshold calcium channels by the synthetic polyamines sFTX-3.3 and FTX-3.3. Mol Pharmacol. 1996 Oct;50(4):939-46.

[3]. M Fatehi, et al. Polyamine FTX-3.3 and polyamine amide sFTX-3.3 inhibit presynaptic calcium currents and acetylcholine release at mouse motor nerve terminals. Neuropharmacology. 1997 Feb;36(2):185-94.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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