Metallo-β-lactamase-IN-5

Names

[ CAS No. ]:
1417737-65-5

[ Name ]:
Metallo-β-lactamase-IN-5

Biological Activity

[Description]:

Metallo-β-lactamase-IN-5 (compound 5c) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-5 shows inhibitory activity against MBLs NDM-1 and VIM-1. Metallo-β-lactamase-IN-5 inhibits HUVECs with an IC50 of 45 μg/mL. Metallo-β-lactamase-IN-5 plus Imipenem exhibits synergistic antimicrobial activity[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Proschak A, Martinelli G, Frank D, Rotter MJ, Brunst S, Weizel L, Burgers LD, Fürst R, Proschak E, Sosič I, Gobec S, Wichelhaus TA. Nitroxoline and its derivatives are potent inhibitors of metallo-β-lactamases. Eur J Med Chem. 2022 Jan 15;228:113975.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H16N4O3

[ Molecular Weight ]:
348.36

Related Compounds