Trimipramine N-Oxide

Trimipramine N-oxide is an active metabolite of the tricyclic antidepressant trimipramine. Trimipramine N-oxide inhibits the human monoamine transporters for noradrenaline (hNAT), serotonin (hSERT), dopamine (hDAT) and the human organic cation transporters (hOCT1 and hOCT2) with IC50s of 11.7, 3.59, 9.4, 9.35 and 27.4 nM, respectively. Trimipramine N-oxide can be used for the research of depression and anxiety[1].

Research Areas >> Neurological Disease

IC50: 3.59 nM (hSERT), 9.35 nM (hOCT1), 9.4 nM (hDAT), 11.7 nM (hNAT), 27.4 (hOCT2)[1]

Trimipramine N-oxide (0-30 μM; 48 h) inhibits hNAT, hSERT, hDAT, hOCT1 and hOCT2 in HEK293 cells[1]. Cell Viability Assay[1] Cell Line: HEK293 cells Concentration: 0-30 μM Incubation Time: 48 hours Result: Dose-dependently inhibited hNAT, hSERT, hDAT, hOCT1 and hOCT2 with IC50s of 11.7, 3.59, 9.4, 9.35 and 27.4 nM in HEK293 cells, respectively.

[1]. Haenisch B, et al. Inhibitory potencies of trimipramine and its main metabolites at human monoamine and organic cation transporters. Psychopharmacology (Berl). 2011 Sep;217(2):289-95.