1-Alaninechlamydocin

Names

[ Name ]:
1-Alaninechlamydocin

[Synonym ]:
9-Benzyl-6-methyl-3-[6-(2-oxiranyl)-6-oxohexyl]decahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetrone
Pyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetrone, decahydro-6-methyl-3-(6-oxiranyl-6-oxohexyl)-9-(phenylmethyl)-

Biological Activity

[Description]:

1-Alaninechlamydocin, a cyclic tetrapeptide, is a potent HDAC inhibitor (IC50=6.4 nM). 1-Alaninechlamydocin induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC

Signaling Pathways >> Epigenetics >> HDAC

[Target]

HDAC:6.4 nM (IC50)

[References]

[1]. Du L, et al. A potent HDAC inhibitor, 1-alaninechlamydocin, from a Tolypocladium sp. induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells. J Nat Prod. 2014;77(7):1753-1757.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
871.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₇H₃₆N₄O₆

[ Molecular Weight ]:
512.598

[ Flash Point ]:
481.1±34.3 °C

[ Exact Mass ]:
512.263489

[ LogP ]:
-1.30

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.593

Related Compounds

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