EM20-25
Names
[ CAS No. ]:
141266-44-6
[ Name ]:
EM20-25
[Synonym ]:
5-(2,4-dioxo-7-chloro-2,3,4,5-tetrahydro-1H-chromeno[2,3-d]pyrimidin-5-yl)pyrimidine-2,4,6(1H,3H,5H)-trione
1,5-Dihydro-7-chloro-5-<5'-pyrimidine-2',4',6'(1'H,3'H,5'H)-trionyl>-2H-chromeno<2,3-d>pyrimidine-2,4(1H,3H)-dione
EM20-25
Bcl-2 Inhibitor III,EM20-25
5-(6-Chloro-2,4-dioxo-1,3,4,10-tetrahydro-2H-9-oxa-1,3-diaza-anthracen-10-yl)-pyrimidine-2,4,6-trione
5-(7-chloro-2,4-dioxo-1,3-dihydro-5H-chromeno[2,3-d]pyrimidin-5-yl)-1,3,5-trih ydropyrimidine-2,4,6-trione
Chemical & Physical Properties
[ Molecular Formula ]:
C15H9ClN4O6
[ Molecular Weight ]:
376.70800
[ Exact Mass ]:
376.02100
[ PSA ]:
157.72000
[ LogP ]:
1.31280
MSDS
Safety Information
[ Symbol ]:
GHS09
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H400
[ Precautionary Statements ]:
P273
[ RIDADR ]:
UN 3077 9 / PGIII
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
PLoS ONE 5(3) , e9924, (2010)
Current limitations of chemotherapy include toxicity on healthy tissues and multidrug resistance of malignant cells. A number of recent anti-cancer strategies aim at targeting the mitochondrial apopto...
The mitochondrial effects of small organic ligands of BCL-2: sensitization of BCL-2-overexpressing cells to apoptosis by a pyrimidine-2,4,6-trione derivative.J. Biol. Chem. 281 , 10066-10072, (2006)
We have investigated the mitochondrial effects of BH3I-2', Chelerythrine, and HA14-1, small organic molecules that share the ability to bind the BH3 domain of BCL-2. All compounds displayed a biphasic...