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flaccidoside II

Names

[ CAS No. ]:
140694-19-5

[ Name ]:
flaccidoside II

[Synonym ]:
3-O-[α-L-rhamnopyranosyl-(1->2)-β-D-xylopyranosyl]oleanolic acid 28-O-[α-L-rhamnopyranosyl-(1->4)-β-D-glucopyranosyl-(1->6)-β-D-glucopyranosyl] ester
3-O-(α-L-rhamnopyranosyl)-(1->2)-(β-D-xylopyranosyl)-oleanolic acid α-L-rhamnopyranosyl-(1->4)-β-D-glucopyranosyl-(1->6)-α-D-glucopyranosyl ester

Biological Activity

[Description]:

Flaccidoside II inhibits proliferation and induces apoptosis in Malignant peripheral nerve sheath tumors (MPNSTs) cell lines. Flaccidoside II ameliorates collagen-induced arthritis in mice. Flaccidoside II is an active triterpenoid saponin constituent from Anemone flaccida rhizome[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Inflammation/Immunology

[References]

[1]. Zhang GB, et al. Corrigendum to "Flaccidoside II ameliorates collagen-induced arthritis in mice" [Eur. J. Pharmacol. 880 (2020) 173155]. Eur J Pharmacol. 2021 Apr 15;897:173963.  

[2]. Han LT, et al. Triterpenoid saponin flaccidoside II from Anemone flaccida triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors via the MAPK-HO-1 pathway. Onco Targets Ther. 2016 Apr 5;9:1969-79.  

Chemical & Physical Properties

[ Molecular Formula ]:
C59H96O25

[ Molecular Weight ]:
1205.38

[ Exact Mass ]:
1204.62000

[ PSA ]:
392.59000

Related Compounds

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