1405-54-5
Names
[ CAS No. ]:
1405-54-5
[ Name ]:
1405-54-5
[Synonym ]:
TYLOSINTARTRATE,BP
pharmasin
TYLOSINE TARTRATE
Tylosin,(2R,3R)-2,3-dihydroxybutanedioate (salt)
TYLOSINTARTRATEPOWDER/GRANULAR
Tylosin Tartrate,For Veterinary Use,BP
Tylosin,[R-(R*,R*)]-2,3-dihydroxybutanedioate (salt)
Tylosin (2R,3R)-2
Tylosin Tartrate (100 mg)
Tylosin Tartrate
[(2S,3R,4Z,6E,9R,11S,12R,13R,14S)-12-{[3,6-Dideoxy-4-O-(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-3-(dimethylamino)-β-D-glucopyranosyl]oxy}-2-ethyl-11-formyl-14-hydroxy-5,9,13-trimethyl-8, 16-dioxooxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-2,3-di-O-methyl-β-L-allopyranoside 2,3-dihydroxysuccinate (1:1)
Oxacyclohexadeca-11,13-diene-7-carboxaldehyde, 15-[[(6-deoxy-2,3-di-O-methyl-β-L-allopyranosyl)oxy]methyl]-6-[[3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-3-(dimethylamino)- β-D-glucopyranosyl]oxy]-16-ethyl-4-hydroxy-5,9,13-trimethyl-2,10-dioxo-, (4S,5R,6R,7S,9R,11E,13Z,15R,16S)-, 2,3-dihydroxybutanedioate (1:1) (salt)
TYLOSIN TARTRATE SALT
Chemical & Physical Properties
[ Density]:
1.24 g/cm3
[ Boiling Point ]:
1116.3ºC at 760 mmHg
[ Molecular Formula ]:
C49H81NO23
[ Molecular Weight ]:
1052.160
[ Flash Point ]:
628.9ºC
[ Exact Mass ]:
1051.519897
[ PSA ]:
353.73000
[ Vapour Pressure ]:
0mmHg at 25°C
[ Storage condition ]:
2-8°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YP0875000
- CHEMICAL NAME :
- Tylosin, tartrate
- CAS REGISTRY NUMBER :
- 1405-54-5
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C45-H77-N-O17.C4-H6-O6
- MOLECULAR WEIGHT :
- 1054.33
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >6200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AAGAAW Antimicrobial Agents Annual. (New York, NY) 1960. For publisher information, see AMACCQ. Volume(issue)/page/year: -,595,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 695 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 4,1,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >6200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AAGAAW Antimicrobial Agents Annual. (New York, NY) 1960. For publisher information, see AMACCQ. Volume(issue)/page/year: -,595,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1354 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 4,1,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 589 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 4,1,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AAGAAW Antimicrobial Agents Annual. (New York, NY) 1960. For publisher information, see AMACCQ. Volume(issue)/page/year: -,595,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 5400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AAGAAW Antimicrobial Agents Annual. (New York, NY) 1960. For publisher information, see AMACCQ. Volume(issue)/page/year: -,595,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 620 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Behavioral - irritability
- REFERENCE :
- VMDNAV Veterinarno-Meditsinski Nauki. Veterinary Science. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.1- 1964- Volume(issue)/page/year: 15,52,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 48 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Behavioral - irritability
- REFERENCE :
- VMDNAV Veterinarno-Meditsinski Nauki. Veterinary Science. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.1- 1964- Volume(issue)/page/year: 15,52,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 432 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AAGAAW Antimicrobial Agents Annual. (New York, NY) 1960. For publisher information, see AMACCQ. Volume(issue)/page/year: -,595,1960 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 5400 mg/kg/6W-I
- TOXIC EFFECTS :
- Blood - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- REFERENCE :
- VMDNAV Veterinarno-Meditsinski Nauki. Veterinary Science. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.1- 1964- Volume(issue)/page/year: 15,52,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2751 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 99 (estimated)
Safety Information
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R42/43
[ Safety Phrases ]:
S22-S36/37