2'-F-2'-ara-N2-ibu-dG Phosphoramidite

Names

[ Name ]:
2'-F-2'-ara-N2-ibu-dG Phosphoramidite

Biological Activity

[Description]:

2'-F-2'-ara-N2-ibu-dG Phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₅H₅₄FN₆O₈P

[ Molecular Weight ]:
856.92

[ Exact Mass ]:
857.367737

[ LogP ]:
9.87

[ Storage condition ]:
2-8℃

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.