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Fotagliptin Benzoate

Names

[ CAS No. ]:
1403496-40-1

[ Name ]:
Fotagliptin Benzoate

Biological Activity

[Description]:

Fotagliptin benzoate is a Dipeptidyl Peptidase IV (DPP-4) inhibitor (IC50=2.27 nM). Fotagliptin benzoate displays great security in rat and dog. Fotagliptin benzoate can be used for Type 2 diabetes mellitus research[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase
Research Areas >> Metabolic Disease

[Target]

DPP-4:22.7 nM (IC50)


[In Vivo]

Fotagliptin benzoate (33 mg/kg 或 110 mg/kg) 在不同剂量下对大鼠和狗是安全的[1]。

[References]

[1]. Wang Z, et al. Development and validation of a UPLC-MS/MS method for simultaneous determination of fotagliptin and its two major metabolites in human plasma and urine. Bioanalysis. 2017 Feb;9(4):381-393.  

Chemical & Physical Properties

[ Molecular Formula ]:
C24H25FN6O3

[ Molecular Weight ]:
464.49

Related Compounds