DAGLβ-IN-1

Names

[ Name ]:
DAGLβ-IN-1

Biological Activity

[Description]:

DAGLβ-IN-1 is an inhibitor of diacylglycerol lipase-β (DAGLβ), serves as a versatile intermediate for the design of DAGL-tailored activity-based probes[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Target]

DAGLβ[1]

[In Vitro]

Diacylglycerol lipase-β (DAGLβ) is a principal biosynthetic enzyme for the endocannabinoid 2-arachidonoylglycerol (2-AG)[1].

[References]

[1]. Ku-Lung Hsu, et al. Development and Optimization of Piperidyl-1,2,3-Triazole Ureas as Selective Chemical Probes of Endocannabinoid Biosynthesis. J Med Chem . 2013 Nov 14;56(21):8257-69.

[2]. Tiziana Bisogno, et al. Cloning of the First sn1-DAG Lipases Points to the Spatial and Temporal Regulation of Endocannabinoid Signaling in the Brain. J Cell Biol. 2003 Nov 10;163(3):463-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₃₄F₃N₅O₄

[ Molecular Weight ]:
561.60

Related Compounds

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