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Cdc7-IN-1

Names

[ CAS No. ]:
1402055-25-7

[ Name ]:
Cdc7-IN-1

Biological Activity

[Description]:

Cdc7-IN-1 (Compound 13) is a highly potent, selective and ATP competitive inhibitor of Cdc7 kinase, with an IC50 value of 0.6 nM at 1 mM ATP and with slow off-rate characteristics. Cdc7-IN-1 potently inhibits Cdc7 activity in cancer cells, and effectively induces cell death[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

IC50: 0.6 nM (Cdc7, at 1 mM ATP)[1]


[References]

[1]. Irie T, et al. Discovery of novel furanone derivatives as potent Cdc7 kinase inhibitors. Eur J Med Chem. 2017 Apr 21;130:406-418.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H16ClN3O4

[ Molecular Weight ]:
409.82

Related Compounds