Amphomycin

Names

[ Name ]:
Amphomycin

Biological Activity

[Description]:

Amphomycin is a lipopeptide antibiotic that inhibits peptidoglycan synthesis and blocks cell wall development. Amphomycin exhibits potent antibacterial activities against methicillin-resistant S. aureus (MRSA), vancomycin-resistant enterococci (VRE), penicillin-gentamicin-erythromycin-resistant S. pneumonia, and linezolid-quinupristin-dalfopristin-resistant enterococci[1][2][3].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Amphomycin (40 μ g/mL; 60 min) leads S. aureus to exhibit cell wall thinning and Park’s nucleotide accumulation[1]. Cell Viability Assay[1] Cell Line: S. aureus whole cells Concentration: 40 μ g/mL Incubation Time: 60 min Result: Resulted in the thinning of cell wall and the accumulation of Park’s nucleotide.

[In Vivo]

Amphomycin (50 mg/kg; p.o.; single) shows low oral availability and (5-10mg/kg; i.v.; single) exhibits a long half-life (5.2-8.0 h in mice and 4.6-7.1 h in rats)[2].

Chemical & Physical Properties

[ Density]:
1.37g/cm3

[ Boiling Point ]:
1693.3ºC at 760 mmHg

[ Molecular Formula ]:
C₅₈H₉₁N₁₃O₂₀

[ Molecular Weight ]:
1290.42000

[ Flash Point ]:
977.9ºC

[ Exact Mass ]:
1289.65000

[ PSA ]:
506.84000

[ LogP ]:
0.52660

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.599

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BU2100000

CHEMICAL NAME :: Amphomycin

CAS REGISTRY NUMBER :: 1402-82-0

LAST UPDATED :: 199109

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(1),317,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 233 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO. Volume(issue)/page/year: 30,9,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 178 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,131,1967

Related Compounds

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