ATPA

Names

[ Name ]:
ATPA

[Synonym ]:
16,16-Dimethyl Prostaglandin E2
ATPA

Biological Activity

[Description]:

ATPA is a selective glutamate receptor GluR5 activator with EC50s of 0.66, 9.5, 1.4, 23, 32, 18, and 14 μM for GluR5wt, GluR5(S741M), GluR5(S721T), GluR5(S721T, S741M), GluR5(S741A), GluR5(S741L), and GluR5(S741V), respectively[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[In Vitro]

ATPA also activates GluR1wt, GluR1(M722S), GluR1(T700S), GluR1(T700S, M722S), GluR1(M722A) with EC50s of 62, 4.6, 97, 14, 97 μM, respectively[1].

[References]

[1]. Nielsen MM, et al. The selective activation of the glutamate receptor GluR5 by ATPA is controlled by serine 741. Mol Pharmacol. 2003 Jan;63(1):19-25.

Chemical & Physical Properties

[ Density]:
1.264g/cm3

[ Boiling Point ]:
406.8ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₁₆N₂O₄

[ Molecular Weight ]:
228.24500

[ Flash Point ]:
199.9ºC

[ Exact Mass ]:
228.11100

[ PSA ]:
109.58000

[ LogP ]:
1.33240

[ Vapour Pressure ]:
2.38E-07mmHg at 25°C

[ Index of Refraction ]:
1.529

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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