2’-Deoxy-2’-fluoro-3’,5’-bis-O-TBDMS-uridine

Names

[ Name ]:
2’-Deoxy-2’-fluoro-3’,5’-bis-O-TBDMS-uridine

Biological Activity

[Description]:

2’-Deoxy-2’-fluoro-3’,5’-bis-O-TBDMS-uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₃₉FN₂O₅Si₂

[ Molecular Weight ]:
474.71

Related Compounds

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