Buddlejasaponin IV

Names

[ CAS No. ]:
139523-30-1

[ Name ]:
Buddlejasaponin IV

[Synonym ]:
y0043
Buddleoglucoside IV

Biological Activity

[Description]:

Buddlejasaponin IV (BS‐IV) exerts anti-inflammatory and cytotoxic effects against cancer cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> COX

[In Vitro]

Buddlejasaponin IV induces cell cycle arrest at G2/M phase and apoptosis in immortalized human oral keratinocytes[1]. Buddlejasaponin IV (BS-IV) exhibits anti-inflammatory effect of through the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via the NF-κB inactivation[2].

[References]

[1]. Young Sun Hwang, et al. Buddlejasaponin IV induces cell cycle arrest at G2/M phase and apoptosis in immortalized human oral keratinocytes. Phytother Res. 2011 Oct;25(10):1503-10.

[2]. Jong-Heon Won, et al. Anti-inflammatory effect of buddlejasaponin IV through the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via the NF-kappaB inactivation. Br J Pharmacol. 2006 May;148(2):216-25.

Chemical & Physical Properties

[ Density]:
1.43g/cm3

[ Melting Point ]:
288-290 ºC

[ Molecular Formula ]:
C₄₈H₇₈O₁₈

[ Molecular Weight ]:
943.12200

[ Exact Mass ]:
942.51900

[ PSA ]:
287.14000

[ Index of Refraction ]:
1.632

[ Water Solubility ]:
Practically insoluble (0.017 g/L) (25 ºC)

Related Compounds

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