139523-30-1

139523-30-1 structure

Name: Buddlejasaponin IV
Chemical Name: Buddlejasaponin IV
CAS Number: 139523-30-1
Molecular Formula: C₄₈H₇₈O₁₈
Molecular Weight: 943.12200
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2017-07-02 02:00:43
Modify Date: 2025-08-20 14:36:43
Buddlejasaponin IV (BS‐IV) exerts anti-inflammatory and cytotoxic effects against cancer cells[1].

Name	Buddlejasaponin IV
Synonyms	y0043 Buddleoglucoside IV

Description	Buddlejasaponin IV (BS‐IV) exerts anti-inflammatory and cytotoxic effects against cancer cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
In Vitro	Buddlejasaponin IV induces cell cycle arrest at G2/M phase and apoptosis in immortalized human oral keratinocytes[1]. Buddlejasaponin IV (BS-IV) exhibits anti-inflammatory effect of through the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via the NF-κB inactivation[2].
References	[1]. Young Sun Hwang, et al. Buddlejasaponin IV induces cell cycle arrest at G2/M phase and apoptosis in immortalized human oral keratinocytes. Phytother Res. 2011 Oct;25(10):1503-10. [2]. Jong-Heon Won, et al. Anti-inflammatory effect of buddlejasaponin IV through the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via the NF-kappaB inactivation. Br J Pharmacol. 2006 May;148(2):216-25.