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8α-Hydroxyhirsutinolide

Names

[ CAS No. ]:
1394156-45-6

[ Name ]:
8α-Hydroxyhirsutinolide

[Synonym ]:
(1R,2E,8S,10R,11S)-8,11-Dihydroxy-6-(hydroxymethyl)-1,10-dimethyl-4,14-dioxatricyclo[9.2.1.03,7]tetradeca-2,6-dien-5-one
7,10-Epoxycyclodeca[b]furan-2(4H)-one, 5,6,7,8,9,10-hexahydro-4,7-dihydroxy-3-(hydroxymethyl)-6,10-dimethyl-, (4S,6R,7S,10R,11E)-

Biological Activity

[Description]:

8α-Hydroxyhirsutinolide is a sesquiterpene lactone. 8α-Hydroxyhirsutinolide inhibits TNF-α-induced NF-κB activity (IC50: 1.9 μM) and NO production. 8α-Hydroxyhirsutinolide can be isolated from Vernonia cinerea[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[References]

[1]. Youn UJ, et al. Anti-inflammatory sesquiterpene lactones from the flower of Vernonia cinerea. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5559-62.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
587.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H20O6

[ Molecular Weight ]:
296.32

[ Flash Point ]:
222.7±23.6 °C

[ Exact Mass ]:
296.125977

[ LogP ]:
0.51

[ Vapour Pressure ]:
0.0±3.7 mmHg at 25°C

[ Index of Refraction ]:
1.610

[ Storage condition ]:
2-8℃

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds