ADAMTS-5 inhibitor 15f

Names

[ Name ]:
ADAMTS-5 inhibitor 15f

Biological Activity

[Description]:

ADAMTS-5 inhibitor 15f is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE; inhibits aggrecanase-mediated (374)ARGS neoepitope release from aggrecan and glycosaminoglycan in response to IL-1β/OSM stimulation.

[References]

References 1. Deng H, et al. J Med Chem. 2012 Aug 23;55(16):7061-79. View Related Products by Target Matrix Metalloproteinase (MMP)

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₃₉N₉O₂S

[ Molecular Weight ]:
541.719

Related Compounds

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