Bromo-PEG4-acid

Names

[ Name ]:
Bromo-PEG4-acid

[Synonym ]:
3,6,9,12-Tetraoxapentadecan-15-oic acid, 1-bromo-
1-Bromo-3,6,9,12-tetraoxapentadecan-15-oic acid
MFCD22574799

Biological Activity

[Description]:

Bromo-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
426.9±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₂₁BrO₆

[ Molecular Weight ]:
329.185

[ Flash Point ]:
212.0±27.3 °C

[ Exact Mass ]:
328.052155

[ LogP ]:
-0.37

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.481

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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