ML252

Names

[ Name ]:
ML252

Biological Activity

[Description]:

ML252 is a selective inhibitor of potassium channel, targeting to KCNQ2 channel (Kv7.2) (IC50=69 nM). ML252 also inhibits Cytochrome P450 with IC50s of 6.1 nM (CYP1A2), 18.9 nM (CYP2C9), 3.9 nM (CYP3A4), 19.9 nM (CYP2D6), respectively[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

CYP1A2:6.1 μM (IC50)

CYP2C9:18.9 μM (IC50)

CYP2D6:19.9 μM (IC50)

CYP3A4:3.9 μM (IC50)

[In Vitro]

ML252 (1 μM；0-48 h) 在大鼠肝脏小体中的内在清除率和随后预测的肝脏清除率分别为 1720 mL/min/kg 和 67.3 mL/min/kg[1]。 ML252 (0.1-0 μM) 在 0.3 μM 开始抑制 CHO-KCNQ2 细胞系的 KCNQ2 电流，在 1 μM 时，完全抑制电流[1]。 ML252 (30 μM; 48 h) 对 CHO 细胞无急性毒性[1]。

[In Vivo]

ML252 具有不适合口服的代谢稳定性[2]。 ML252 (10 mg/kg，3 mg/mL；腹腔注射；单剂量；1 h 后测定) 在大鼠模型中的 B:P 比值为1.9，大脑绝对水平为 672 nM[1]。

[References]

[1]. Yu H, et al. Identification of a novel, small molecule inhibitor of KCNQ2 channels. 2011 Oct 28 [updated 2013 Feb 25]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–.

[2]. Cheung YY, et al. Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K(v)7.2 (KCNQ2) channel pharmacology: identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a potent, brain penetrant K(v)7.2 channel inhibitor. J Med Chem. 2012 Aug 9;55(15):6975-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₄N₂O

[ Molecular Weight ]:
308.41700

[ Exact Mass ]:
308.18900

[ PSA ]:
32.34000

[ LogP ]:
4.55710

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.