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VU0455691

Names

[ CAS No. ]:
1392443-41-2

[ Name ]:
VU0455691

Biological Activity

[Description]:

VU0455691 is a potent, selective orthosteric M1 mAChR antagonist (pIC50=6.64; IC50=0.23 µM for hM1)[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR
Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> mAChR

[References]

[1]. Melancon BJ, et al. Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012. Bioorg Med Chem Lett. 2012;22(15):5035-5040.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H25N5O3S

[ Molecular Weight ]:
463.55200

[ Exact Mass ]:
463.16800

[ PSA ]:
95.09000

[ LogP ]:
2.86670